研究業績

論文

2025年

• "Interleukin 1 Receptor Antagonist (IL‐1ra) Production and Expression Dynamics in Mammary Glands After Lipopolysaccharide Infusion "
  Nur Laili Marufah, Takahiro Nii, Naoki Suzuki, Jirapat Jaisue, Naoki Isobe
  Animal Science Journal 96 (2025).

  • DOI: doi.org/10.1111/asj.70047
• "Relationship of teat canal score to milk somatic cell count, pathogen infection, and antimicrobial components in Holstein dairy cows"
  Keiichi HISAEDA, Naomi OHTA, Naoki YAMAMOTO, Akira GOTO, Yoichi INOUE, Yasunori SHINOZUKA, Naoki SUZUKI, Naoki ISOBE
  Journal of Veterinary Medical Science (2025).

  • DOI: 10.1292/jvms.24-0510
• "Association of iron-acquisition-related genes and milk lactoferrin concentration with the growth of Escherichia coli and Klebsiella pneumoniae in milk of dairy cows "
  Rin Furukido, Takeshi Tsuka, Yuzo Kurokawa, Naoki Isobe, Naoki Suzuki
  Microbial Pathogenesis 200, 107372 (2025).

  • DOI: 10.1016/j.micpath.2025.107372
• "Antimicrobial Component Concentrations in the Milk of Peripartum Goats "
  Jin‐Kun Sun, Zi‐Long Liang, Takahiro Nii, Naoki Suzuki, Naoki Isobe
  Animal Science Journal 96, 1 (2025).

  • DOI: 10.1111/asj.70029
• "Determining causal pathogens and inflammatory state of mastitis in dairy cows via Gram staining of precipitates in milk "
  Naoki Suzuki, Naoki Isobe
  Frontiers in Veterinary Science 13 (2025).

  • DOI: 10.3389/fvets.2024.1492564

2024年

• "Colchicine can keep the viability of bacteria in mastitic milk by preventing leukocyte phagocytosis in dairy cow and goat"
  Keiichi Hisaeda, Masato Hirano, Naoki Suzuki, Naoki Isobe
  Frontiers in Veterinary Science 11 (2024).

  • DOI: 10.3389/fvets.2024.1469586
• "Effect of milking time on yield, composition, and antimicrobial components of milk in lactating goats"
  Zi-Long Liang, Takahiro Nii, Naoki Suzuki, Yusaku Tsugami, Toshihisa Sugino, Naoki Isobe
  Animal Science Journal 95, 1, e13970 (2024).

  • DOI: 10.1111/asj.13970
• "Effect of low milking frequency on the concentration of antimicrobial proteins in goat milk"
  Rika Harada, Takahiro Nii, Naoki Suzuki, Naoki Isobe
  Veterinary Immunology and Immunopathology 272, 110774 (2024).

  • DOI: 10.1016/j.vetimm.2024.110774
• "Longitudinal and Cross-Sectional Studies to Evaluate Changes in Cow Milk Microbiota Over The Lactation Stages"
  Yasunori Shinozuka, Naoki Suzuki, Manabu Kitsukawa, Mayu Hayashi, Nagomu Suenaga, Yuko Shimizu, Tomomi Kurumisawa, Kazuhiro Kawai
  ACTA VETERINARIA-BEOGRAD 74, 2, 236-245 (2024).

  • DOI: 10.2478/acve-2024-0016
• "Concentrations of antimicrobial components in milk of Japanese Black cows and their differences from dairy cows"
  Naoki Suzuki, Konosuke Otomaru, Naoki Isobe
  Journal of Veterinary Medical Science 86, 4, 436-439 (2024).

  • DOI: 10.1292/jvms.23-0365
• "Effect of sodium butyrate treatment at the basolateral membranes on the tight junction barrier function via a monocarboxylate transporter in goat mammary epithelial cells"
  Yusaku Tsugami, Naoki Suzuki, Takahiro Nii, Naoki Isobe
  Experimental Cell Research 436, 1, 113944 (2024).

  • DOI: 10.1016/j.yexcr.2024.113944
• "Effect of different inflammation states on the antimicrobial components in milk of goat udders after milking cessation"
  Jinkun Sun, Naoki Suzuki, Takahiro Nii, Naoki Isobe
  Animal Science Journal 95, e13926 (2024).

  • DOI: 10.1111/asj.13926
• "Concentrations of antimicrobial components in milk at dry off and postpartum and their relationships to new high somatic cell counts at quarter level in dairy cows"
  Naoki Suzuki, Rika Harada, Yusaku Tsugami, Takahiro Nii, Naoki Isobe
  Journal of Dairy Research 16 (2024).

  • DOI: 10.1017/S0022029924000050

2023年

• "Effects of oral administration of lipopolysaccharide derived from Pantoea agglomerans on innate immunity of mammary glands in dairy goats  "
  Naoki Suzuki, Fika Yuliza Purba, Hiroyuki Inagawa, Yoshinori Hattori , Naoki Isobe
  Veterinary Immunology and Immunopatology 265, 110664 (2023).

  • DOI: 10.1016/j.vetimm.2023.110664
• "Effect of intramammary lipopolysaccharide challenge after repeated intrauterine infusion of lipopolysaccharide on the inflammation status of goat mammary glands"
  Jirapat Jaisue, Takahiro Nii, Naoki Suzuki, Toshihisa Sugino, Naoki Isobe
  Theriogenology 212, 104-110 (2023).

  • DOI: 10.1016/j.theriogenology.2023.09.006
• "抗菌因子，腸内細菌等を活用した畜産現場における感染症予防の未来（総説）"
  鈴木直樹
  家畜感染症学会誌 12, 2 (2023).
• "Menthol application on healthy and inflamed goat udders changes antimicrobial components in milk"
  Ruri Ohno, Naoki Suzuki, Yusaku Tsugami, Takahiro Nii, Ken Kobayashi, Naoki Isobe
  Animal Science Journal 94（1）, e13832 (2023).

  • DOI: 10.1111/asj.13832
• "Effects of Intramammary Antimicrobial Treatment on the Milk Microbiota Composition in Mild Clinical Bovine Mastitis Caused by Gram-Positive Bacteria"
  Mayu Hayashi, Yasunori Shinozuka, Tomomi Kurumisawa, Takuya Yagisawa, Nagomu Suenaga, Yuko Shimizu, Naoki Suzuki, Kazuhiro Kawai
  Animals 13, 713 (2023).

  • DOI: 10.3390/ani13040713

2022年

• "Effects of ozonized glycerin on inflammation of mammary glands induced by intramammary lipopolysaccharide infusion in goats "
  Naoki Suzuki, Masato Hirano, Yasunori Shinozuka, Kazuhiro Kawai, Yoshiharu Okamoto, Naoki Isobe
  Animal Science Journal 93, 1 (2022).

  • DOI: 10.1111/asj.13780
• "Effect of 6‐n‐propyl‐2‐thiouracil or dexamethasone administration on the responses of antimicrobial components in goat milk to intramammary lipopolysaccharide infusion "
  Naoki Suzuki, Fika Yuliza Purba, Takahiro Nii, Naoki Isobe
  Animal Science Journal 93, 1 (2022).

  • DOI: 10.1111/asj.13773
• "Effect of temporary cessation of milking and estradiol combination on the antimicrobial components in goat milk "
  Fika Yuliza Purba, Yoshihisa Ishimoto, Takahiro Nii, Naoki Suzuki, Naoki Isobe
  Research in Veterinary Science 152, 387-394 (2022).
• "Effect of repeated intrauterine infusion of lipopolysaccharides on mastitis in goats"
  Jirapat Jaisue, Takahiro Nii, Naoki Suzuki, Yusaku Tsugami, Naoki Isobe
  Theriogenology 193, 87-92 (2022).

  • DOI: 10.1016/j.theriogenology.2022.09.009
• "Investigating mammary glands of lactating goats for the presence of tertiary lymphoid organs"
  Yusaku Tsugami, Sayaka Nakayama, Naoki Suzuki, Takahiro Nii, Naoki Isobe
  Frontiers in Immunology 13 (2022).

  • DOI: 10.3389/fimmu.2022.941333
• "Sodium Acetate and Sodium Butyrate Differentially Upregulate Antimicrobial Component Production in Mammary Glands of Lactating Goats "
  Yusaku Tsugami, Naoki Suzuki, Takahiro Nii, Naoki Isobe
  Journal of Mammary Gland Biology and Neoplasia 27, 133-144 (2022).

  • DOI: 10.1007/s10911-022-09519-5
• "Effects of frequent teat stimulation on antimicrobial component production in mammary glands of lactating goats "
  Yusaku Tsugami, Rika Harada, Takahiro Nii, Naoki Suzuki, Naoki Isobe
  Veterinary Immunology and Immunopathology 9, 249 (2022).

  • DOI: 10.1016/j.vetimm.202
• "Rapid determination of pathogens in mastitic milk of dairy cows using Gram staining "
  Naoki SUZUKI, Sohei KANEKO, Naoki ISOBE
  Journal of Veterinary Medical Science 84, 3, 325-329 (2022).

  • DOI: 10.1292/jvms.21-0631
• "Regression tree analysis of the relationship between the concentrations of antimicrobial components and the microbiota of normal milk from dairy cows"
  SHINOZUKA Yasunori, SUZUKI Naoki, KANEKO Sohei, KAWAI Kazuhiro, SHIMIZU Yuko, IMANISHI Tadashi, OHNO Ayumu, TAKAHASHI Mano, ISOBE Naoki
  Journal of Veterinary Medical Science 84, 3, 310-318 (2022).

  • DOI: 10.1292/jvms.21-0541
• "Effect of oral administration of colostrum on inflammation in the udders of dairy cows suffering from mastitis"
  Naoki ISOBE, Tomoyasu KUROSE, Naoki SUZUKI, Tomoko KOSHIISHI, Kazutoshi UENO, Keiichi HISAEDA
  Journal of Veterinary Medical Science 84, 1, 59-63 (2022).

  • DOI: 10.1292/jvms.21-0505

2021年

• "Local heat treatment of goat udders influences innate immune functions in mammary glands "
  Yusaku Tsugami, Yuki Ishiba, Naoki Suzuki, Takahiro Nii, Ken Kobayashi, Naoki Iosbe
  Journal of Mammary Gland Biology and Neoplasia 26, 4, 387-397 (2021).

  • DOI: 10.1007/s10911-022-09509-7
• "Examination of the microbiota of normal cow milk using MinIONTM nanopore sequencing "
  Yasunori SHINOZUKA, Kazuhiro KAWAI, Tomomi KURUMISAWA, Yuko SHIMIZU, Tadashi IMANISHI, Ayumu OHNO, Mano TAKAHASHI, Sohei KANEKO, Naoki SUZUKI
  Journal of Veterinary Medical Science 83, 11, 1620-1627 (2021).

2020年

• "Seasonal variations in the concentration of antimicrobial components in milk of dairy cows"
  Naoki Suzuki, Fika Yuliza Purba, Yoshiaki Hayashi, Takahiro Nii, Yukinori Yoshimura, Naoki Isobe
  Animal Science Journal 91, e13427 (2020).

  • DOI: 10.1111/asj.13427
• "Outcome prediction from the first examination in clinical mastitis using ultrasonography in dairy cows"
  Naoki Suzuki, Tomoyasu Kurose, Sohei Kaneko, Asako Haraguchi, Naoki Isobe
  Animal Science Journal 91, e13452 (2020).

  • DOI: 10.1111/asj.13452
• "Association of endometritis and ovarian follicular cyst with mastitis in dairy cows "
  Fika Yuliza PURBA, Naoki SUZUKI, Naoki ISOBE
  Journal of Veterinary Medical Science 83, 2, 338-343 (2020).

  • DOI: 10.1292/jvms.20-0652